Gain of function: A mutationplugin-autotooltip__default plugin-autotooltip_bigMutation: a change in the DNA of a gene that results in a change of phenotype compared to a reference wildtype allele. See also: mutant. that has increased or different activity as the wildtypeplugin-autotooltip__default plugin-autotooltip_bigWildtype: a reference strain of an organism that scientists operationally define as “normal” to which mutants are compared. Not to be confused with wild organisms. alleleplugin-autotooltip__default plugin-autotooltip_bigAllele: a version of a gene. Alleles of a gene are different if they have differences in their DNA sequence.. Both hypermorphicplugin-autotooltip__default plugin-autotooltip_bigHypermorphic mutation: assuming a wildtype allele has 100% gene function, a hypermomorphic mutation is a mutant allele that has >100% gene function. Also called a gain of function mutation. and neomorphicplugin-autotooltip__default plugin-autotooltip_bigNeomorphic mutation: a mutation that gives a gene a new or different function than the wildtype allele. Also called a gain of function mutation. mutationsplugin-autotooltip__default plugin-autotooltip_bigMutation: a change in the DNA of a gene that results in a change of phenotype compared to a reference wildtype allele. See also: mutant. can be called gain of function mutationsplugin-autotooltip__default plugin-autotooltip_bigMutation: a change in the DNA of a gene that results in a change of phenotype compared to a reference wildtype allele. See also: mutant..