Loss of function: a general term used to describe mutantplugin-autotooltip__default plugin-autotooltip_bigMutant: an individual that has a different phenotype than wildtype and likely contains one more mutations that cause this difference. allelesplugin-autotooltip__default plugin-autotooltip_bigAllele: a version of a gene. Alleles of a gene are different if they have differences in their DNA sequence. that have less activity than wildtypeplugin-autotooltip__default plugin-autotooltip_bigWildtype: a reference strain of an organism that scientists operationally define as “normal” to which mutants are compared. Not to be confused with wild organisms.. Amorphicplugin-autotooltip__default plugin-autotooltip_bigAmorphic mutation: assuming a wildtype allele has 100% gene function, an amorphic mutation is a mutant allele that has 0% gene function. Also called a null mutation or a complete loss of function mutation. and hypomorphicplugin-autotooltip__default plugin-autotooltip_bigHypomorphic mutation: assuming a wildtype allele has 100% gene function, a hypomomorphic mutation is a mutant allele that has <100% gene function. Also called a partial loss of function mutation. mutationsplugin-autotooltip__default plugin-autotooltip_bigMutation: a change in the DNA of a gene that results in a change of phenotype compared to a reference wildtype allele. See also: mutant. are loss of function mutationsplugin-autotooltip__default plugin-autotooltip_bigMutation: a change in the DNA of a gene that results in a change of phenotype compared to a reference wildtype allele. See also: mutant..