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--- chapter_20 [2024/09/14 22:50] – [Recessive lethal alleles] mike
+++ chapter_20 [2024/09/15 09:31] (current) – mike
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 <- chapter_19|Chapter 19^table_of_contents|Table of Contents^chapter_21|Chapter 21 ->
-<typo fs:x-large>Chapter 19. Effects of inbreeding</typo>
+<typo fs:x-large>Chapter 20. Effects of inbreeding</typo>
 In this chapter we will examine how inbreeding between close relatives (also known as consanguineous matings) influences the appearance of autosomal recessive traits. Inbreeding will not make a difference for dominant traits because they need only be inherited from one parent or for X-linked traits in males since they are inherited from the mother.
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 </table>
-If the adjusted frequency of stillbirths and neonatal deaths from first cousin marriages is $f_\text{cousins}=0.07$, and this frequency is adjusted at a rate of 0.016 above the general population, this means that the average frequency for recessive lethal alleles in both grandparents is $\frac{0.07}{0.016}=4.4$. Each grandparent (and therefore a typical person in the population) has an average of $\frac{4.4}{2}=2.2$ recessive lethal alleles in their genome. Our estimate of the lethal mutation rate, as well as our estimate of the percentage of essential genes, was reasonably close.
+If the adjusted frequency of stillbirths and neonatal deaths from first cousin marriages is $f_\text{cousins}=0.07$, and this frequency is adjusted at a rate of 0.016 above the general population, this means that the average frequency for recessive lethal alleles in both grandparents is $\frac{0.07}{0.016}=4.4$. Each grandparent (and therefore a typical person in the population) has an average of $\frac{4.4}{2}=2.2$ recessive lethal alleles in their genome. Our estimate of the recessive loss of function mutation rate (10<sup>-4</sup>), as well as our guess of the percentage of essential genes (50%), were reasonably close.